Table 2.
Demonstrated interaction of OATPs with adaptor proteins
| OATP | PDZK1 | PDZK2 | NHERF1 | NHERF2 | IKEPP | |
|---|---|---|---|---|---|---|
| rOATP1A1 | yes | (P. Wang, et al., 2005) | ||||
| mOATP1A1 | yes | yes | yes | yes | (Sugiura, et al., 2010) | |
| hOATP1A2 | yes | yes | yes | yes | (Kato, et al., 2004) | |
| mOATP1A4 | yes | yes | yes | yes | (Sugiura, et al., 2010) | |
| mOATP1A5 | yes | yes | yes | yes | (Sugiura, et al., 2010) | |
| mOATP1A6 | yes | yes | yes | yes | (Sugiura, et al., 2010) | |
| mOATP1B2 | yes | yes | yes | (Sugiura, et al., 2010) | ||
| hOATP1C1 | yes | (Kato, et al., 2004) | ||||
| mOATP1C1 | yes | yes | yes | yes | (Sugiura, et al., 2010) | |
| mOATP2A1 | yes | (Sugiura, et al., 2010) | ||||
| mOATP2B1 | yes | yes | (Sugiura, et al., 2010) | |||
| hOATP3A1 | yes | yes | yes | (Kato, et al., 2004) | ||
| mOATP3A1 | yes | yes | yes | (Sugiura, et al., 2010) |
NHERF: Na+/H+ exchanger regulatory factor
IKEPP: intestinal and kidney-enriched PDZ protein
yes means that an interaction was demonstrated, an empty cell means that the respective
OATP did not interact or an interaction was not demonstrated