Physical maps of the sfa-hts and isd loci in Staphylococcus lugdunensis. (A) Staphyloferrin A (SA) biosynthetic and uptake locus. Shown is the homologous locus in S. aureus versus that which is present in all sequenced genomes of S. lugdunensis. Note that the SA biosynthetic locus in S. lugdunensis carries a deletion that eliminates two genes completely (sfaA and sfaD), along with the promoter for the remaining two genes (sfaB and sfaC). The deleted region is indicated between the dashed lines. Asp23, alkaline shock protein 23. (B) Shown is the ∼65-kb region of the S. lugdunensis strain HKU09-01 genome (spanning orfs SLGD_00056 to SLGD_00116) with the tandemly duplicated isd-sir locus. The duplicated region is shown between the dashed vertical lines. Abbreviations are as follows, with predicted or hypothetical functions: ABC, component of an ATP-binding cassette transporter; ATP-A,B,C, K+-ATPase components A, B, and C, respectively; mem, membrane protein; FMN, FMN binding protein; NAT,N-acetyltransferase; marR, MarR-type regulator; hyp, hypothetical; Red, reductase; Pase, phosphatase.