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Construction of the FB-iPSC-CM regulatory circuit. (a) Schematic of pluripotent reprogramming and TD for FB-iPSC-CM system, showing that FBs can be induced either to reprogram into pluripotent stem cells (PSCs) and later differentiate into CMs, or to transdifferentiate into CMs through a direct or indirect pathway. (b) The gene regulatory model circuit in this work, constructed based on the IPA (@Ingenuity) database. (Online version in colour.)
