Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Jun 6;4(3):20130070. doi: 10.1098/rsfs.2013.0070

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2014 The Author(s) Published by the Royal Society. All rights reserved.

PMC Copyright notice

Figure 8. — Potential bistability in the programmed cell-death decision. (From Zhang et al. [42].) (a) Programmed cell death is triggered by activation of BAX proteins in the mitochondrial outer membrane. BAX is activated by BH3 proteins and inhibited by BCL proteins. (b) The balance between BH3 and BCL protein concentrations determines the activity of BAX. The mathematical model suggests that the BAX response exhibits bistability. In the model, the switch from living to dying is one-way. (Online version in colour.)