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. 2014 Jun 6;4(3):20130076. doi: 10.1098/rsfs.2013.0076

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© 2014 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0/, which permits unrestricted use, provided the original author and source are credited.

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Figure 8. — Effect of VIP on individual cells and the SCN network. PRCs predicted by the model for (a) a single cell and (b) the SCN network (circles) in response to a VIP pulse show that single cells can be shifted much more easily than the SCN network (note the difference in scales). Experimentally determined phase shifts for application of 100 nM VIP to the SCN from [47] are labelled as cross symbols in (b) for comparison. VIP pulses given to the single cell (labelled as regions c and d in (a) and denoted by grey vertical lines) can either (c) cause the cell to become arrhythmic or (d) phase shift it. In particular, pulses between CT17.3 and CT20.5 cause the cell to lose rhythms, shown as a gap on the PRC (single-cell parameters are given in the electronic supplementary material). (e) Restoring VIP signalling (denoted by a red vertical line) to an uncoupled network of half rhythmic (blue), half arrhythmic (green) cells quickly restores rhythms and synchrony to the network.