Fig 1. TQ suppresses the proliferation of MM cell lines.
A, Chemical structure of TQ. B, doxorubicin-sensitive and doxorubicin-resistant RPMI 8266 cells, melphalan-sensitive and melphalan-resistant RPMI 8266 cells, and bortezomib-sensitive and bortezomib-resistant RPMI 8266 cells were plated in triplicate, treated with different concentrations of TQ for 24, 48 and 72 h, and then subjected to MTT assay to analyze proliferation of cells. Each point on line is an average of triplicate value. C, CD138+ cells were isolated from MM patient samples as described in Materials and Methods. The cells were plated in triplicate, treated with different concentrations of TQ and then subjected to MTT assay to analyze proliferation of cells. Columns, mean; bars, SD. *, p < 0.05.