Table 1. Summary of cancer cell line inhibition assays used in meta-analysis.
| Assay group ID | Assay Title | PubChem Assay ID | Compounds in assay: Active (Tested) | Compounds with targets*: Active (Tested) |
|---|---|---|---|---|
| NCI60 | NCI 60 assays | (AID: 1 to 145) | ~2000 (~40 000) |
~220 (~2 000) |
| HPDE_C7 | Fluorescent HTS Cytotoxicity/Cell viability assay (HPDE-C7K cells) | 431 | 1 068 (61 593) |
1 032 (~46 000) |
| H69AR_Lung | Human H69AR Lung Tumor Cell Growth Inhibition Assay - 86K Screen | 598 | 5142 (80 068) |
4 844 (~63 000) |
| Lacking_Gene | Compounds that Suppress the Growth of Human Colon Tumor Cells Lacking Oncogenic Beta Catenin Expression | 818 | 2052 (136 706) |
2 011 (~105 000) |
| Lacking_Gene | Compounds that Suppress the Growth of Cells with a Deletion of the PTEN Tumor Suppressor | 827 | 1659 (136 779) |
1621 (~105 000) |
| Cancer_Stem_Cells | Inhibitors of Cancer Stem Cells | 2717 | (3 190) (297 011) |
3 100 (~196 000) |
| Synthetic_lethality | qHTS for induction of synthetic lethality in tumor cells producing 2HG | 686971 | 7 452 (328 241) |
7327 (~230 000) |
*
compounds with at least one experimentally validated protein target