Table 2. Top individual targets enriched among molecules producing a cytotoxic effect in the IGROV1 Ovarian cell line.
P-value FDR corrected | Target (Gene Symbol) | Odds Ratio | The number of active compounds known to target gene | The total number of active compounds (IC50 < 10−6) | The number of inactive compounds known to target gene | The total number of inactive compounds (IC50 >10−6) |
---|---|---|---|---|---|---|
1.82E-42 | NCOA3 | 22.2 | 68 | 231 | 37 | 2004 |
2.32E-42 | NR5A1 | 18.1 | 73 | 231 | 50 | 2004 |
7.76E-42 | NR5A2 | 17.3 | 73 | 231 | 52 | 2004 |
9.26E-38 | NCOA1 | 7.3 | 57 | 231 | 26 | 2004 |
3.07E-36 | IDH1 | 24.9 | 88 | 231 | 123 | 2004 |
8.29E-34 | CFTR | 9.4 | 86 | 231 | 128 | 2004 |
1.57E-33 | PAX8 | 8.7 | 71 | 231 | 76 | 2004 |
1.09E-28 | MITF | 11.3 | 81 | 231 | 137 | 2004 |
2.49E-28 | NFE2L2 | 7.4 | 77 | 231 | 123 | 2004 |