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. 2014 Jan 21;5(3):659–666. doi: 10.18632/oncotarget.1597

Table 3. Top individual targets enriched among molecules producing cytotoxic effects in HCT116 cells with a targeted deletion of the PTEN.

P-value FDR corrected Target (Gene Symbol) Odds Ratio The number of active compounds known to target gene The total number of active compounds (IC50 < 10−6) The number of inactive compounds known to target gene The total number of inactive compounds (IC50 >10−6)
MITF 1.00e-300 78.6  456 1621   510 102910
GMNN 1.00e-300 13.6  682 1621  5220 102910
IDH1 1.00e-300 22.1  476 1621  1901 102910
ATXN2 1.00e-300 74.2  421 1621   484 102910
EPAS1 1.00e-300 46.0  367 1621   650 102910
CFTR 1.00e-300 32.7  336 1621   816 102910
TDP1 1.00e-300 12.2 1236 1621 21478 102910
SMAD3 2.45e-286 24.5  328 1621  1053 102910
HIF1A 4.75e-261 40.1  248 1621   462 102910