Table 3. Top individual targets enriched among molecules producing cytotoxic effects in HCT116 cells with a targeted deletion of the PTEN.

P-value FDR corrected	Target (Gene Symbol)	Odds Ratio	The number of active compounds known to target gene	The total number of active compounds (IC50 < 10−6)	The number of inactive compounds known to target gene	The total number of inactive compounds (IC50 >10−6)
MITF	1.00e-300	78.6	456	1621	510	102910
GMNN	1.00e-300	13.6	682	1621	5220	102910
IDH1	1.00e-300	22.1	476	1621	1901	102910
ATXN2	1.00e-300	74.2	421	1621	484	102910
EPAS1	1.00e-300	46.0	367	1621	650	102910
CFTR	1.00e-300	32.7	336	1621	816	102910
TDP1	1.00e-300	12.2	1236	1621	21478	102910
SMAD3	2.45e-286	24.5	328	1621	1053	102910
HIF1A	4.75e-261	40.1	248	1621	462	102910