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. 2014 Jan 21;5(3):659–666. doi: 10.18632/oncotarget.1597

Table 5. Statistics for MITF-related poly-pharmacological patterns in HCT116 cells with a targeted deletion of the PTEN gene.

P-value FDR corrected Target/pattern (Gene Symbol) Odds Ratio The number of active compounds known to target gene/pattern The total number of active compounds (IC50 < 10−6) The number of inactive compounds known to target gene/pattern The total number of inactive compounds (IC50 >10−6)
< 1.00e-286 MITF 78.6 456 1621  510 102910
< 1.00e-286 ATNX2 74.2 421 1621  484 102910
< 1.00e-286 SMAD3 24.5 328 1621 1053 102910
6.55e-279 MITF and SMAD3 188.5 189 1621   72 102910
< 1.00e-300 MITF and ATXN2 240.1 247 1621   77 102910
< 1.00e-230 MITF and ATXN2 and SMAD3 500.2 117 1621   16 102910