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. 2014 Feb 11;5(3):788–801. doi: 10.18632/oncotarget.1772

Figure 4. Blocking the mTOR signaling largely abolishes the promoting effect of LIF on invasion and migration of breast cancer cells.

Figure 4

(a) MCF7, T47D and MDA-MB-231 cells were treated with LIF (100 ng/ml) alone or in combination with rapamycin (20 nM). The invasion and migration abilities of cells were determined by trans-well assays. Upper panels: representative images; lower panels: quantifications of average number of cells/field. (b) MCF7-LIF, T47D-LIF, MDA-MB-231-LIF and their control cells were treated with or without rapamycin (20 nM). The invasion and migration abilities of cells were determined. Data are presented as mean ± SD (n=3). *: p<0.001; #: p<0.01 .