Table 2. Multivariate analyses according to the Cox proportional hazards model.
Results obtained in all 78 APL patients included in the study (top), and in patients younger than 60 years (bottom). HR indicates hazard ratio; CI, confidence interval.
| Overall cohort | ||
|---|---|---|
| HR (95% CI) | P | |
| Variable | ||
| Age, <60 vs > 60 years | 6.58 (2.6-16.1) | <0.0001 |
| FLT3, ITD vs WT + TDK | 3.9 (1.2-11.8) | 0.01 |
| LEF1 expression, LEF1high vs LEF1low | 3.3 (1.0-10.5) | 0.03 |
| Sanz score, L-I vs H | 1.7 (0.5−5.0) | 0.3 |
| Young (<60 years) patients | ||
| HR (95% CI) | P | |
| Variable | ||
| LEF1 expression, LEF1high vs LEF1low | 5.4 (1.0-27.0) | 0.04 |
| FLT3, ITD vs WT + TDK | 0.4 (0.08-2.0) | 0.2 |
| Sanz's score, L-I vs H | 1.0 (0.2−3.8) | 0.9 |