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. Author manuscript; available in PMC: 2014 Apr 23.
Published in final edited form as: Eur J Pharmacol. 2013 Feb 1;703(0):18–24. doi: 10.1016/j.ejphar.2013.01.034

Figure 1.

Figure 1

Neuronal activity of cultured neocortical neurons from wild type (black) and 5(H105R) mutant (grey) mice under control conditions. All activity phases (up states) were collected, divided in bins of 10ms and averaged. The action potential firing frequency of multi-unit recordings is high at the beginning of the up state and declines in a gradual fashion. Comparison between genotypes is given as effect size (Hedges'g including 95% confidence interval). An effect size of 1 would indicate that the two genotypes are one standard deviation apart. A significant difference between genotypes can be assumed, if the 95% confidence interval does not cross the zero-line. Apart from the first 10ms, where slices from the 5(H105R) mutant showed slightly higher activity, neuronal activity between the two genotypes is almost identical.