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. Author manuscript; available in PMC: 2014 Apr 23.
Published in final edited form as: Eur J Pharmacol. 2013 Feb 1;703(0):18–24. doi: 10.1016/j.ejphar.2013.01.034

Figure 2. Firing pattern of cultured slices from the neocortex and actions of the 5-selective GABAA receptor modulator SH-053-2′F-R-CH3.

Figure 2

(A) Original extracellular recording from a cultured neocortical slice. Eight bursts of action potentials (up states) are separated by neuronal silence (down states).

(B) SH-053-2′F-R-CH3 in a concentration of 10 μM reduces the number of up states and simultaneously prolongs them. Additionally, the number of action potentials during up states is increased in the presence of SH-053-2′F-R-CH3.