Skip to main content
. Author manuscript; available in PMC: 2014 Apr 23.
Published in final edited form as: Eur J Pharmacol. 2013 Feb 1;703(0):18–24. doi: 10.1016/j.ejphar.2013.01.034

Figure 5.

Figure 5

Schematic picture of a pyramidal neuron from the cortex. While GABAA receptors containing 1-, 2-, and 3-subunits are enriched at the soma, 5-containing GABAA receptors are mainly found at distal dendritic locations. The unselective benzodiazepine diazepam targets all these GABAA receptor subtypes, resulting in a depression of network activity. The 5-prefering compound SH-053-2′F-R-CH3 acts predominantly at dendritic GABAA receptors. Due to their specific location and properties 5-containing GABAA receptors are capable of inducing excitation during phases of ongoing neuronal activity.