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. Author manuscript; available in PMC: 2015 Mar 20.
Published in final edited form as: Brain Res. 2014 Jan 25;1554:36–48. doi: 10.1016/j.brainres.2014.01.036

Fig. 7.

Fig. 7

Approximated electrophysiological behavior of the estimated free brain concentrations, based on total brain concentrations measured 20 min after i.p. administration of SH-I-048A (0.5, 2 and 10 mg/kg) and diazepam (2 mg/kg; DZP 2). The estimated free concentrations of SH-I-048A are given in Table 2, while the estimated free concentration of 2 mg/kg diazepam equals 58.46 nmol/kg (Savić et al., unpublished data). The bars indicate the stimulation of the individual αxβ3γ2 GABAA receptors at these concentrations, as extrapolated from data presented in Fig. 1.