Table 4.

Metrics of model performance and evaluation of bias.

Study	Model performance					Bias*
	Discrimination	Calibration reported	Model fit reported	Reclassification reported	Analysis	Study participation	Study attrition	Prognostic factor measurement	Outcome measurement	Confounding measurement and account	Analysis
Kasiske et al. [25] 2000	No	No	No	No	Cox PH	Unsure	Unsure	Yes	Yes	yes	yes
Ducloux et al. [10] 2004	No	No	No	No	Cox PH (no continuous FHS risk)	Unsure	Unsure	Unsure	Yes	yes	no
Kiberd and Panek [28] 2008	Yes	Yes	No	No	ROC	Yes	No	Unsure	Unsure	yes	yes
Silver et al. [11] 2011	No	No	No	No	Cox PH (no continuous FHS risk)	Yes	No	Partially	No	Partially	yes
Israni et al. [33] 2010	Yes	Yes	Yes	No	Cox PH/KM	Unsure	Unsure	Unsure	Yes	yes	yes
Soveri et al. [21] 2012	Yes	Yes	No	No	Cox Ph	Yes	Unsure	Unsure	Yes	yes	yes
Soveri et al. [35] 2013	Yes	Yes	NA	No		Yes	Unsure	No	Yes	NA	NA

*Table 1 describes the criteria for bias assessment. Yes: adequately meets requirements for bias assessment (low risk of bias). No: does not adequately meet the requirements for bias assessment (high risk of bias). Partially: the study does address the component, but not in a satisfactory manner. Unsure: the authors did not make definitive statements to meet the requirements, but they are not necessarily absent from the study itself.