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Brief summary in miRNA biogenesis. (1) initial transcription by RNA polymerase (Pol II) into primary miRNA (pri-miRNA) (2) processing by Drosha-DGCR8 into a precursor miRNA (pre-miRNA) (3) export of the pre-miRNA via Exportin-5 from the nucleus to the cytoplasm (4) cleaved by the RNase enzyme Dicer into double-stranded miRNAs (5) incorporation into the RNA-induced silencing complex (RISC).
