Table 2.
Upregulated oncogenic miRNAs in HCC.
| miRNA | Target genes | Characteristics | References |
|---|---|---|---|
| MiR-15a | Bcl-2, cyclin D1, AKT3 | Proliferation, apoptosis | [65] |
| MiR-16-1 | Bcl-2, cyclin D1, AKT3 | Proliferation, apoptosis | [65] |
| MiR-17 | c-Myc, E2F | Angiogenesis | [66, 67] |
| MiR-18 | c-Myc, E2F | Angiogenesis | [66, 67] |
| MiR-19 | c-Myc, E2F | Angiogenesis | [66, 67] |
| MiR-20a | c-Myc, E2F | Angiogenesis | [66, 67] |
| MiR-21 | PTEN | metastasis | [68] |
| MiR-25 | Bim | Apoptosis | [69] |
| MiR-92-1 | c-Myc, E2F | Angiogenesis | [66, 67] |
| MiR-93 | Bim | Apoptosis | [69] |
| MiR-106b | Bim | Apoptosis | [69] |
| MiR-148a | PTEN | Metastasis | [70] |
| MiR-155 | RhoA, TLR | Metastasis | [56, 71] |
| MiR-216a | PTEN | Metastasis | [72] |
| MiR-221 | Bmf; CDKN1B/p27/Kip1; CDKN1C/p57/Kip2, PTEN | Apoptosis; proliferation, angiogenesis | [73–77] |
| MiR-222 | AKT, PTEN | Metastasis, angiogenesis | [51, 74, 78] |
| MiR-224 | Bcl-2, Bcl-w | Apoptosis | [79] |
| MiR-519d | PTEN | Metastasis | [80] |