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. Author manuscript; available in PMC: 2014 Apr 23.
Published in final edited form as: Twin Res Hum Genet. 2008 Feb;11(1):48–54. doi: 10.1375/twin.11.1.48

Table 1.

Theoretical Total Number of Pairs Required for a Power of 80% to Reject the AE Hypothesis When it is False at a Type-I Error Rate of 0.05, and Achieved Statistical Power (in %) for that Number from Simulations

True model Maximum likelihood pMZ
h2 c2 0.51 Optimised2
0.8 0.1 2663 / 80 1598 (0.13) / 78
0.6 0.3 262 / 82 159 (0.06) / 80
0.4 0.5 80 / 82 48 (0.04) / 79
0.2 0.7 34 / 86 20 (0.08) / 82
0.6 0.1 3425 / 79 2574 (0.25) / 80
0.4 0.3 356 / 81 252 (0.17) / 80
0.2 0.5 114 / 83 79 (0.11) / 79
0.4 0.1 4486 / 80 3617 (0.27) / 79
0.2 0.3 464 / 81 368 (0.21) / 80
0.2 0.1 5394 / 79 4701 (0.27) / 80

Note:

1

Estimate power (in %) from simulation are shown after the theoretical results.

2

Lowest total number of pairs, with the proportion of MZ pairs in brackets, from a search in 0.01 step units. Estimates of power (in %) from simulation are shown after the theoretical results.