FIG. 3.

Troglitazone treatment increases the number of adipocytes in the BM. Mice were treated with troglitazone (5 mg/kg, three times per week) or DMSO control for 4 weeks. (A) Percent increase in total body weight of the mice over the treatment period. These data represent the mean of three independent experiments, with five mice in each group for each experiment. (B) Quantification of the number of adipocytes in each section. The dotted lines represent an individual experiment where five mice were examined in each group. The solid line represents the mean of all experiments. (C) Quantification of the volume of the adipocytes expressed as a percentage of the total BM volume of the same sections. These data represent the mean of three independent experiments, with five sections in each group for each experiment. (D) Quantification of the number of tartarate-resistant acid phosphatase-positive (TRAP+) cells in the metaphysis region of each section. These data represent the mean of three independent experiments, with five sections in each group for each experiment. *P<0.05.