FIG. 6.

Evolution of immunolabeling for laminin (LN; left column, red in merge panels), and rat endothelial cell antigen (RECA-1) (middle column, green in merge panels) on spinal cord sections from lesioned untreated (Lesion) and chondroitinase ABC (ChABC)-treated (Les+ChABC) animals, compared with intact (control) animals (A,B, merge image in C). (D–I) 2 weeks, (J–0) 4 weeks post-injury; (D–F, J–L) untreated, (G–I, M–O) ChABC-treated animals. Note that within the injury site, RECA-1–positive blood vessels are less frequent than laminin-immunoreactivity would have suggested. At 4 weeks after ChABC treatment, LN shows important colocalization with RECA-1. F,I,L,O are higher magnification merge images of insets within the same row. Bars: A–C,F,I,L,O, 30 μm; D,E,G,H,J,K,M,N, 200 μm. Color image is available online at www.liebertpub.com/neu