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. 2014 Apr 16;8:104. doi: 10.3389/fncel.2014.00104

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Copyright © 2014 Gitik, Kleinhaus, Hadas, Reichert and Rotshenker.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The phagocytosis of degenerated myelin is augmented in SIRPα-KD microglia. (A) A representative (one of three) immunoblot of SIRPα and GAPDH. SIRPα levels are reduced in Balb/C microglia infected with SIRPα-shRNA (SIRPα-KD) compared with control microglia infected with non-target Luciferase-shRNA (Con-Luc). (B) Phagocytosis of degenerated myelin is augmented in SIRPα-KD microglia compared with phagocytosis by control microglia (Con-Luc). Phagocytosis by SIRPα-KD microglia was calculated as a percentage of phagocytosis by control microglia that was defined as 100%. Values of individual experiments each performed in triplicates and averages ±SE are given. Significance of difference by Mann–Whitney is ***p < 0.001.