Table 3.
List of transcripts exclusively differentially expressed in aged Tg4–42.
| ID | Gene name | Gene description | GO biological process annotation/functions | log2 Fold change | Adjusted p-value |
|---|---|---|---|---|---|
| MGI:1914517 | Uqcc2 | Ubiquinol-cytochrome-c reductase complex assembly factor 2 | Regulation of insulin secretion | 1.17 | 2.18E-02 |
| ATP production | |||||
| MGI:5474852 | Beta-S | Hemoglobin, beta adult s chain | Iron ion binding | 1.14 | 1.31E-02 |
| Oxygen binding | |||||
| MGI:108391 | Kif1a | Kinesin family member 1A | Microtubule motor activity | 0.90 | 1.77E-02 |
| ATP-binding | |||||
| MGI:2153272 | Trrap | Transformation/transcription domain-associated protein | Phosphotransferase Activity | −0.86 | 4.74E-02 |
| Regulation of transcription | |||||
| MGI:1194504 | Kcnj10 | ATP-sensitive inward rectifier potassium channel 10 | Potassium channel activity | −0.93 | 3.76E-02 |
| ATP-binding | |||||
| MGI:3039582 | Lmtk3 | Lemur tyrosine kinase 3 | Protein tyrosine kinase activity | −0.94 | 3.98E-02 |
| MGI:1343180 | Vgf | Nerve growth factor inducible | Neuropeptide hormone activity | −0.95 | 3.64E-02 |
| Synaptic plasticity | |||||
| Neurosecretory protein (Jahn et al., 2011 no. 284) | |||||
| Regulation of energy balance (Jahn et al., 2011 no. 284) | |||||
| Important for modulating neuronal activity (Cocco et al., 2010 no. 286) | |||||
| MGI:106374 | Zmiz2 | Zinc finger MIZ domain containing protein 2 | Zinc ion binding | −0.98 | 1.90E-02 |
| Ligand-dependent nuclear receptor transcription coactivator activity | |||||
| MGI:1194488 | Slc32a1 | Vesicular inhibitory amino acid transporter solute carrier family 32 (GABA vesicular transporter), member 1 | Glycine transporter activity | −1.02 | 3.76E-02 |
| Amino acid-polyamine transporter activity | |||||
| Neurotransmitter transport | |||||
| MGI:1277171 | Dcx | Doublecortin | Microtubule binding | −1.03 | 4.42E-02 |
| Protein kinase binding | |||||
| Neurogenesis | |||||
| MGI:101947 | Hnrnpd | Heterogeneous nuclear ribonucleoprotein D | Regulation of transcription | −1.04 | 1.99E-02 |
| RNA binding and telomeric DNA binding | |||||
| MGI:109591 | Nfic | Nuclear factor I/C | Transcription factor activity | −1.10 | 1.90E-02 |
| DNA binding | |||||
| MGI:2441726 | BC005537 | cDNA sequence BC005537 | Unknown | −1.11 | 9.46E-03 |
| MGI:2673998 | Arhgap33 | Rho GTPase activating protein 33 | Rac GTPase activator activity | −1.12 | 1.08E-02 |
| Phosphatidylinositol binding | |||||
| MGI:1330828 | Cdk5r2 | Cyclin-dependent kinase 5 activator 2 (p39) | Lipid binding | −1.14 | 1.04E-02 |
| Cyclin-dependent protein kinase 5 | |||||
| Activator activity | |||||
| Neuron-specific | |||||
| MGI:2674092 | Zfp609 | Zinc finger protein 609 | Zinc ion binding | −1.17 | 1.90E-02 |
| MGI:1915454 | 2900060 | RIKEN cDNA 2900060B14 gene | Unknown | −1.18 | 2.43E-02 |
| B14Rik | |||||
| MGI:1351334 | Syn3 | Synapsin III | Catalytic activity | −1.25 | 1.30E-02 |
| ATP-binding | |||||
| MGI:1920907 | Fbrsl1 | Fibrosin-like 1 | Unknown | −1.25 | 2.43E-02 |
| MGI:106589 | Hivep3 | Human immunodeficiency virus type I enhancer binding protein 3 | DNA binding | −1.26 | 5.18E-03 |
| Zinc ion binding | |||||
| Transcription factor |