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Comparison of the two transgenic mouse models 5XFAD and Tg4–42.
| Features | 5XFAD | Tg4–42 |
|---|---|---|
| Mutations | APP695 (Swedish, Florida, London) | None |
| PSEN-1 (M146L and L286V) | ||
| Genetic background | C57Bl6 | C57Bl6 |
| Transient intraneuronal Aβ | Yes | Yes |
| Prevalence of Aβ variants | Aβ1–42 > 1–40 > 4–42 > pyroglutamate3-42 | only Aβ4–42 |
| Plaques | Plaque deposits starting at 3 months | None |
| Neuron loss | 38% loss in cortical layer 5 | 49% loss in CA1 |
| Gliosis | Yes | Yes |
| Behavioral deficits | Yes | Yes |
