Table 1.

Biochemical parameters of the astrocyte network model.

Symbol	Description	Value	Units
IP3R KINETICS
d1	IP3 binding affinity	0.13	μM
O2	Inactivating Ca2+ binding rate	0.2	μM−1s−1
d2	Inactivating Ca2+ binding affinity	1.049	μM
d3	IP3 binding affinity (with Ca2+ inactivation)	0.9434	μM
d5	Activating Ca2+ binding affinity	0.08234	μM
CALCIUM FLUXES
CT	Total ER Ca2+ content	2	μM
ρA	ER-to-cytoplasm volume ratio	0.185	–
ΩC	Maximal Ca2+ release rate by IP3Rs	6	s−1
ΩL	Maximal Ca2+ leak rate	0.11	s−1
OP	Maximal Ca2+ uptake rate	0.9	μM s−1
KP	Ca2+ affinity of SERCA pumps	0.05	μM
IP3 PRODUCTION
Oδ	Maximal rate of IP3 production by PLCδ	0.7	μM s−1
Kδ	Ca2+ affinity of PLCδ	0.1	μM
κδ	Inhibiting IP3 affinity of PLCδ	1.5	μM
IP3 DEGRADATION
Ω5P	Maximal rate of IP3 degradation by IP-5P	0.21	s−1
O3K	Maximal rate of IP3 degradation by IP3−3K	4.5	μM s−1
KD	Ca2+ affinity of IP3-3K	1	μM
K3K	IP3 affinity of IP3-3K	0.7	μM
IP3 DIFFUSION
F	GJC IP3 permeability (linear)	2	s−1
	GJC IP3 permeability (non–linear)	2	μM s−1
Iθ	Threshold IP3 gradient for diffusion	0.3	μM
ωI	Scaling factor of diffusion	0.05	μM
Ibias	IP3 bias	2	μM
SIMULATION
T	Simulation time	200	s
ts	Stimulation time	200	s

The full model equations are given in Supplementary Material S1.