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. 2014 Apr 16;5:78. doi: 10.3389/fgene.2014.00078

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Copyright © 2014 Rieder and Carleton.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Metabolism of 6-Mercaptopurine (6-MP). Metabolism of 6-MP via Hypoxanthine-guanine Phosphoribosyltransferase produces active Thioguanine nucleotide analogues while metabolism of 6-MP by Thiopurine Methyltransferase produces inactive 6-methylmercaptopurine. Genetically determined variations in 6-MP metabolism can produce significant differences in efficacy and safety.