Skip to main content
. 2014 Apr 16;5:51. doi: 10.3389/fneur.2014.00051

Figure 3.

Figure 3

The effect of atenolol (A) or metoprolol (B) on the HR-response to tyramine in WKY and SHR. The rats were pre-treated as outlined in the legends. After overall and step-by-step curve evaluations with Repeated Measures Analyses of Variance and Covariance (please see Statistical Analyses), group differences were located at 15 min (* in brackets right of curves), as indicated. Comparisons were made in (A) between the controls and losartan-treated groups, between the losartan- and AdrX + losartan-pre-treated groups and between corresponding groups without and with pre-treatment with atenolol; and in (B) between the controls and the metoprolol-treated groups, and between the metoprolol- and the losartan + metoprolol-treated groups. In the same order as in the legends, HR baselines prior to tyramine was in (A) 340 ± 9, 338 ± 9, 333 ± 13, 312 ± 10, 310 ± 8, 304 ± 10, 307 ± 16 bpm in WKY and 394 ± 5, 360 ± 10†, 343 ± 13†, 325 ± 9†, 372 ± 6†, 328 ± 21†, 297 ± 5† bpm in SHR (†; P  ≤ 0.0083 compared to the controls), and in (B) 340 ± 9, 300 ± 8†, 318 ± 14 bpm in WKY and 394 ± 5, 333 ± 12†, 292 ± 7† bpm in SHR (†P  ≤ 0.004). * In brackets – P  ≤ 0.05 after curve evaluations with Bonferroni-adjusted P-values.