Table 2.
Placental Expression of Angiogenic Factors/Receptors
| Placental compartment and gene of interest | C+Saline (n=12) | H+Ad.VEGF (n=18) | H+Saline/Ad.LacZ (n=27) | p |
|---|---|---|---|---|
| Maternal caruncle | ||||
| VEGF | 27.3±3.04a | 23.7±1.75ab | 20.3±1.26b | 0.036 |
| FLT1 | 18.8±2.26a | 18.1±2.36a | 12.5±1.36b | 0.031 |
| KDR | 23.8±2.40a | 23.2±2.52a | 17.4±1.43b | 0.040 |
| NOS3 | 28.6±2.82 | 37.6±3.25 | 33.5±2.65 | 0.185 |
| FGF2 | 15.7±1.54 | 13.8±1.28 | 12.5±1.15 | 0.280 |
| ANG1 | 24.0±1.622 | 21.1±1.65 | 20.1±1.48 | 0.291 |
| ANG2 | 14.0±1.17 | 14.7±0.85 | 12.4±0.69 | 0.110 |
| TEK | 21.6±2.63 | 22.9±1.51 | 19.8±1.33 | 0.370 |
| SGC | 16.5±1.52 | 16.2±1.15 | 13.6±0.96 | 0.138 |
| Fetal cotyledon | ||||
| VEGF | 26.5±3.53 | 30.6±2.67 | 30.9±2.59 | 0.579 |
| FLT1 | 15.1±2.42 | 13.0±1.50 | 14.6±1.44 | 0.699 |
| KDR | 17.0±2.44 | 17.6±1.59 | 18.4±1.80 | 0.877 |
| NOS3 | 16.1±2.17 | 21.5±3.01 | 19.6±1.87 | 0.383 |
| FGF2 | 9.9±1.07 | 10.6±0.58 | 11.3±0.69 | 0.430 |
| ANG1 | 21.9±1.64 | 20.9±0.94 | 23.1±0.90 | 0.312 |
| ANG2 | 13.0±0.79a | 16.0±0.73b | 16.9±0.80b | 0.010 |
| TEK | 14.0±0.79a | 16.8±0.71b | 16.2±0.61b | 0.049 |
| SGC | 8.9±0.90 | 9.3±0.81 | 8.3±0.40 | 0.517 |
ANG1, angiopoietin 1; ANG2, angiopoietin 2; FGF2, fibroblast growth factor 2; FLT1, fms-related tyrosine kinase 1 (VEGF receptor 1); KDR, kinase insert domain receptor (VEGF receptor 2); NOS3, nitric oxide synthase; SGC, soluble guanylate cyclase (nitric oxide receptor); TEK, endothelial tyrosine kinase; VEGF, vascular endothelial growth factor.
p-Values shown are for overall ANOVA. Mean values within a row with unlike superscripts are significantly different (p<0.05 for individual post hoc comparisons). All data are presented as mean±SEM.