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. 2014 Feb 25;25(4):350–363. doi: 10.1089/hum.2013.218

FIG. 7.

FIG. 7.

The protective immunity elicited by heterologous prime-boost vaccination is not inhibited by treatment with HU. (A) A/Sn mice were immunized, infected, and treated with HU as depicted. (B) Parasitemia of each individual control mouse primed with pcDNA3 and boosted with Adβ-Gal (n=12). (C) Parasitemia of each individual ASP-2-immunized mouse (n=12). (D) Parasitemia of each individual ASP-2-immunized mouse treated with HU (n=10). Although the day of peak parasitemia was different for each mouse, we used the maximal values for statistical comparison. The results of the statistical comparisons are below panel D. (E) Kaplan–Meier survival curves of the different groups were compared, and the results showed that ASP-2-immunized mice treated or not with HU survived significantly longer (p<0.01) than control animals injected with βGal. Results are from two experiments pooled.