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. Author manuscript; available in PMC: 2014 Apr 23.
Published in final edited form as: Free Radic Biol Med. 2011 Apr 19;51(1):216–224. doi: 10.1016/j.freeradbiomed.2011.04.026

Fig. 4. Nrf2-deficient mice exhibit more pronounced neuronal cell loss after retinal I/R injury.

Fig. 4

(A) Ganglion cell layer counting was performed as described in Methods. The number of cells in ganglion cell layer (GCL) of the I/R retina was significantly less than that of control retina (CN) in Nrf2 −/−mice 2 days after I/R injury, while no significant change was observed in the wild-type mice (n = 5, ** p < 0.01). (B) Apoptotic DNA Cleavage ELISA was performed 48 hrs after I/R injury. Nucleosomal DNA fragmentation was significantly increased in wild-type mice after I/R injury. There was a further increase in apoptotic DNA cleavage in Nrf2 −/− mice after I/R injury, beyond what was observed in wild-type mice. n = 5, * p < 0.05; ** p < 0.01.