Polymicrobial sepsis leads to severe leucopenia. The two groups of mice, wild-type (WT) and toll-like receptor 2−/−, underwent sham or cecum ligation and puncture (CLP) procedures. Twenty-four hours later, total white blood cells (WBC), neutrophils, lymphocytes, and monocytes were counted. Each error bar represents mean ± se of six to nine mice. **p < .01; ‡p < .001 vs. the sham mice. KO, knockout (toll-like receptor 2−/−).