Table 2.
Serial echocardiographic measurements before and after cecum ligation and puncture
| Sham | CLP | |||||
|---|---|---|---|---|---|---|
| Baseline | 12 hrs | 24 hrs | Baseline | 12 hrs | 24 hrs | |
| Heart rate, bpm | ||||||
| WT | 657 ± 10 | 682 ± 13 | 678 ± 6 | 659 ± 9 | 545 ± 31c | 540 ± 31c |
| KO | 645 ± 11 | 663 ± 10 | 650 ± 17 | 650 ± 5 | 620 ± 21 | 560 ± 26c |
| Strain rate, 1/sec | ||||||
| WT | 20 ± 1 | 21 ± 2 | 20 ± 2 | 21 ± 2 | 14 ± 2c | 12 ± 2c |
| KO | 19 ± 2 | 20 ± 1 | 19 ± 3 | 20 ± 1 | 17 ± 2a | 15 ± 1b,c |
| LV internal dimension diastole, mm | ||||||
| WT | 3.2 ± 0.1 | 3.0 ± 0.1 | 3.0 ± 0.1 | 3.0 ± 0.0 | 3.3 ± 0.1 | 3.2 ± 0.1 |
| KO | 3.1 ± 0.1 | 3.1 ± 0.0 | 3.1 ± 0.0 | 3.2 ± 0.0 | 3.3 ± 0.0 | 3.1 ± 0.1 |
| LV internal dimension systole, mm | ||||||
| WT | 1.6 ± 0 | 1.6 ± 0 | 1.6 ± 0.0 | 1.5 ± 0 | 1.7 ± 0.1 | 1.74 ± 0.1 |
| KO | 1.4 ± 0.1 | 1.5 ± 0 | 1.4 ± 0 | 1.5 ± 0 | 1.6 ± 0 | 1.4 ± 0.1a |
| Fractional shortening, % | ||||||
| WT | 51 ± 2 | 50 ± 1 | 49 ± 1 | 51 ± 1 | 47 ± 2 | 46 ± 3 |
| KO | 53 ± 1 | 52 ± 1 | 53 ± 1 | 53 ± 1 | 52 ± 1 | 53 ± 1a |
WT, wild-type; KO, knockout; CLP, cecum ligation and puncture; LV, left ventricle.
a
p < 0.05 and
b
p < .01 vs. WT CLP;
c
p < .01 vs. Baseline. WT: n = 6–10; KO: n = 6–9.