Hypo-IRAS rats exhibit significant increases in body weight that can be prevented or reversed by food restriction. No differences in body weight were observed in the hypo-Con group, ad lib Hypo-IRAS and hypo-IRAS Prevention group 5 days after lentivirus injection (Day 5). Conversely, at Day 23 hypo-IRAS rats provided ad lib access to food exhibited significant increases in body weight, increases not observed in the hypo-IRAS Prevention group. At this time, the hypo-IRAS rats were further divided into a group that continued to have ad lib access to food and the Reversal group. At Day 40, hypo-Con rats, hypo-IRAS Prevention rats and hypo-IRAS Reversal rats all exhibited body weights that were significantly different from the hypo-IRAS rats provided ad lib access to food. [Day 5: F(3,18) 2.931, p = 0.06. Day 23: F(3,18) 11.723, p = 0.0002. Day 40: F(3,18) 11.0, p = 0.0002. # = compared to hypo-Con rats; $ = compared to Prevention rats; % = compared to Reversal rats.]