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In vitro insulin-stimulated phosphorylation of the insulin receptor (phospho-IR) is reduced in the hypothalamus of hypo-IRAS rats irrespective of access to food. Hypo-IRAS rats provided ad libitum access to food, the hypo-IRAS Prevention group and the hypo-IRAS Reversal group exhibited significant decreases in phospho-IR levels when compared to Hypo-Con rats. [F(3,20) 12.53, p = 0.0002. * = compared to hypo-Con]
