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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Hematol Oncol Clin North Am. 2014 Jan 18;28(2):287–299. doi: 10.1016/j.hoc.2013.11.003

Table 1.

Adenosine receptor subtypes17,32

Adenosine receptor subtypes
Characteristics A1 A2A A2B A3
Predominant tissue/cell expression
  • Lung

  • Heart

  • Brain

  • Leukocytes

  • Lung

  • Brain

  • Vasculature

  • Leukocytes

  • Lung

  • Colon

  • Vasculature

  • Leukocytes

  • Erythrocytes

  • Penis

  • Lung

  • Liver

  • Heart

  • Brain

  • Leukocytes

Actions
  • Negative chronotropic

  • ↑inflammation

  • Vasodilation

  • ↓inflammation

  • ↑inflammation in lung and colon

  • ↓inflammation

Affinity for adenosine High High Low High
Major disease associations
  • Sepsis

  • SCD

  • Ischemia

  • Arthritis

  • Wound healing

  • SCD

  • Asthma

  • COPD

  • IBD

  • Asthma

  • Arthritis