Figure 1.

Potentiating effects of H₂O₂ on responses mediated by GABA_Aρ1 receptors expressed in Xenopus laevis oocytes. Representative traces of GABA_Aρ1 receptors mediated Cl⁻ currents elicited by GABA (0.3 μM) applications (indicated as bars) in the absence (control) or presence of H₂O₂ (500 μM). H₂O₂ was either applied during the GABA-evoked responses (A) or co-applied with GABA (B), flanked by control responses to GABA. (C) Lack of effect of H₂O₂ on a representative baseline current recorded from a non-transfected oocyte. For this and the subsequent figures, the oocytes were voltage-clamped at −70 mV. Scale bars indicate current amplitude and time.