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. 2014 Apr 11;171(9):2291–2299. doi: 10.1111/bph.12581

Figure 4.

Figure 4

Intracellular cysteine C364 mediates H2O2 modulation of responses mediated by GABAAρ1 receptors. Mutation of the C364 affects the potentiating actions of H2O2. (A) H2O2 (500 μM) failed to potentiate GABAAρ1C364A.; ***P < 0.0001, n = 5 and (B) GABAAρ1C364S receptor responses (0.3 μM GABA); ***P < 0.0001, n = 8. (C) Concentration-response curves for GABAAρ1C364S receptors in the absence (control) or presence of H2O2 (500 μM). Response amplitudes were expressed as fraction of 30 μM GABA-evoked currents (maximal response).