Figure 6.

Visual performance evaluation using the combined treatment following sarin exposure. Both rat eyes were treated topically with the indicated drugs, tropicamide (Trop) with two drops of various oximes (2.5%), 20 min following PG (A, C, E) or 1 μg sarin (B, D, F) exposure. Ocular measurements and the visual test were conducted 15 min later. Visual performance was evaluated under controlled light conditions (170 lux) using the ‘cued MWM’ paradigm. The parameters examined and compared between groups were escape latency (A), path length (B) and swimming speed (C); n = 12 for each group. The first block shows the average of the initial four trials of 12 rats, and the second block represents the following four trials average for the same animals. Significant (by manova) differences between groups are indicated by asterisks at a level of *P < 0.001. (B, D) *P < 0.001, versus sarin; saline in the same block; (E) *P < 0.001, versus Trop + HI-6 in the same block.