Figure 6.

Treatment with C3 and anti-CXCL10 induces neurite outgrowth and myelination. Cut cultures (B) were immunolabelled with SMI-31 (red) and anti-PLP antibody (green) upon treatment with C3 1 μg mL⁻¹ (C), anti-CXCL10 2 μg mL⁻¹ (D), C3 and anti-CXCL10 0.2 μg mL⁻¹ (E) and C3 and anti-CXCL10 2 μg mL⁻¹ (F). The average neurite density (G) and myelination surrounding the lesion (H), normalized to control, and neurite outgrowth across the lesion (I) are shown. Scale bar 100 μm. *P < 0.05, **P < 0.001; significant differences between control and cut, and treatments and cut.