Table 1.
Effects of RF-Id on the activity of COX-1/2, mPGES-1 and cPLA2
| Enzyme/assay | Remaining activity at 10 μM (%) or IC50 of compound (μM) | Remaining activity at given concentration of reference compound (%) |
|---|---|---|
| Isolated COX-1 | 89.6 ± 13.6% | (Indomethacin, 10 μM) 22.2 ± 2.6% |
| COX-1 in platelets | 93.8 ± 3.3% | (Indomethacin, 10 μM) 5.9 ± 3.1% |
| Isolated COX-2 | 76.4 ± 7.6% | (Indomethacin, 10 μM) 43.0 ± 2.7% |
| COX-2 in A549 cells | 7.3 ± 0.5 μM | (Celecoxib, 5 μM) 25.2 ± 4.9% |
| Isolated cPLA2 | 79.9 ± 8.2% | (RSC-3388, 5 μM) 11.6 ± 5.9% |
| mPGES-1, cell-free | 71.6 ± 6.9% | (MK886, 10 μM) 26.7 ± 8.0% |
Data are given as mean ± SEM, n = 3–4.