Table 2. Association between α-tocopherol level during treatment and histological endpoints among Vit E treated participants in PIVENS and TONIC.
| Response | Yes | No | p value | ||
| Median | Min-Max | Median | Min-Max | ||
| PIVENS | |||||
| NASH Resolution * | |||||
| α-toco at week 48 | 1.33 | 0.57–2.21 | 1.31 | 0.50–3.29 | - |
| α-toco at week 96 | 0.98 | 0.49–1.89 | 1.31 | 0.50–2.48 | 0.006 |
| Week 48/baseline | 2.29 | 0.97–5.74 | 2.05 | 1.42–4.9 | - |
| Week 96/baseline | 1.8 | 0.53–3.13 | 2.03 | 0.85–4.54 | 0.006 |
| Overall Improvement * | |||||
| α-toco at week 48 | 1.28 | 0.57–2.69 | 1.37 | 0.50–3.29 | - |
| α-toco at week 96 | 1.03 | 0.49–1.89 | 1.32 | 0.50–2.48 | 0.021 |
| Week 48/baseline | 2.22 | 0.97–5.74 | 2.09 | 1.42–3.83 | - |
| Week 96/baseline | 1.88 | 0.84–3.24 | 1.99 | 0.85–4.42 | - |
| TONIC | |||||
| NASH Resolution | |||||
| α-toco at week 48 | 1.29 | 0.57–5.06 | 0.99 | 0.43–1.85 | - |
| α-toco at week 96 | 1.09 | 0.50–3.39 | 0.82 | 0.47–1.63 | 0.05 |
| Week 48/baseline | 2.18 | 0.64–5.01 | 2.15 | 1.14–3.48 | - |
| Week 96/baseline | 2.22 | 0.48–3.35 | 1.55 | 1.18–4.91 | - |
| Overall Improvement | |||||
| α-toco at week 48 | 1.11 | 0.43–1.91 | 1.07 | 0.48–5.06 | - |
| α-toco at week 96 | 1.08 | 0.47–1.99 | 1.12 | 0.52–3.39 | - |
| Week 48/baseline | 2.25 | 0.64–4.29 | 2.10 | 1.08–5.01 | - |
| Week 96/baseline | 2.05 | 0.48–3.34 | 2.13 | 1.02–4.91 | - |
*See text for definitions.