Table 3. Association between CYP4F2 polymorphisms and plasma α-tocopherol levels.

	V433M		W12G
	r	p	r	p
PIVENS
Baseline α-toco	0.01	-	0.04	-
α-toco at week 48	−0.35	0.003	−0.17	-
α-toco at week 96	−0.18	-	-0.14	-
Week 48/baseline	−0.43	0.0002	−0.27	0.019
Week 96/baseline	−0.22	-	-0.20	-
TONIC
Baseline α-toco	−0.23	0.004	−0.10	-
α-toco at week 48	−0.34	0.026	−0.04	-
α-toco at week 96	−0.21	-	−0.19	-
Week 48/baseline	−0.08	-	−0.05	-
Week 96/baseline	0.04	-	−0.08	-

Analyses were based on linear regression which assumed an additive effect of the 433V or 12G allele

on Vit E metabolism (e.g. assigning the M/M, M/V and V/V genotypes to 0, 1 and 2). The association

between baseline level and CYP4F2 polymorphisms was tested in all cases for each trial,

while the association during treatment was tested only in the patients treated with Vit E. The r values refer to correlation coefficients.