Table 3. Mutations (including Missense point mutations/deletion/insertion) frequencies in 45 genes (737 loci) of human lung cancer patients at different differentiation levels.

Genes	Number of samples with mutations (Mutation frequency in 76 samples)	Number of high differentiation samples with mutations (Mutation frequency in 15 samples)	Number of low differentiation samples with mutations (Mutation frequency in 33 samples)	Number of middle differentiation samples with mutations (Mutation frequency in 27 samples)	Number of unknown samples with mutations (Mutation frequency in 1 samples)
ABL1	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
AKT1	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
ALK	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
APC	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
ATM	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
BRAF	2(2.6%)	0(0.0%)	1(3.0%)	1(3.7%)	0(0.0%)
CDH1	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
CDKN2A	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
CSF1R	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
CTNNB1	3(3.9%)	0(0.0%)	0(0.0%)	3(11.1%)	0(0.0%)
EGFR	32(42.1%)	13(86.7%)	5(15.2%)	14(51.9%)	0(0.0%)
ERBB2	1(1.3%)	0(0.0%)	1(3.0%)	0(0.0%)	0(0.0%)
ERBB4	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
FBXW7	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
FGFR1	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
FGFR2	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
FGFR3	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
FLT3	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
GNAS	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
HNF1A	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
HRAS	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
IDH1	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
JAK3	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
KDR	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
KIT	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
KRAS	4(5.3%)	0(0.0%)	2(6.1%)	2(7.4%)	0(0.0%)
MET	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
MLH1	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
MPL	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
NOTCH1	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
NPM1	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
NRAS	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
PDGFRA	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
PIK3CA	2(2.6%)	0(0.0%)	1(3.0%)	1(3.7%)	0(0.0%)
PTEN	1(1.3%)	0(0.0%)	0(0.0%)	1(3.7%)	0(0.0%)
PTPN11	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
RB1	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
RET	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
SMAD4	1(1.3%)	0(0.0%)	0(0.0%)	1(3.7%)	0(0.0%)
SMARCB1	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
SMO	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
SRC	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
STK11	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
TP53	17(22.4%)	3(20.0%)	7(21.2%)	7(25.9%)	0(0.0%)
VHL	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)