Table 6. Mutations (including Missense point mutations/deletion/insertion) frequencies in 45 genes (737 loci) of human lung cancer samples from heavy smokers (smoking index> = 400), light smokers (smoking index<400) and non-smokers.

Genes	Number of samples with mutations in 76 samples (Mutation frequency)	Number of samples of heavy smokers with mutations (Mutation frequency in 17 samples)	Number of samples of light smokers samples with mutations (Mutation frequency in 6 samples)	Number of samples of non-smoker samples with mutations (Mutation frequency in 52 samples)	Number of unknown samples with mutations (Mutation frequency in 1 sample)
ABL1	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
AKT1	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
ALK	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
APC	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
ATM	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
BRAF	2(2.6%)	1(5.9%)	0(0.0%)	1(1.9%)	0(0.0%)
CDH1	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
CDKN2A	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
CSF1R	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
CTNNB1	3(3.9%)	0(0.0%)	0(0.0%)	3(5.8%)	0(0.0%)
EGFR	32(42.1%)	3(17.6%)	2(33.3%)	27(51.9%)	0(0.0%)
ERBB2	1(1.3%)	0(0.0%)	0(0.0%)	1(1.9%)	0(0.0%)
ERBB4	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
FBXW7	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
FGFR1	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
FGFR2	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
FGFR3	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
FLT3	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
GNAS	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
HNF1A	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
HRAS	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
IDH1	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
JAK3	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
KDR	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
KIT	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
KRAS	4(5.3%)	3(17.6%)	0(0.0%)	1(1.9%)	0(0.0%)
MET	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
MLH1	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
MPL	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
NOTCH1	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
NPM1	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
NRAS	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
PDGFRA	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
PIK3CA	2(2.6%)	1(5.9%)	0(0.0%)	1(1.9%)	0(0.0%)
PTEN	1(1.3%)	0(0.0%)	0(0.0%)	1(1.9%)	0(0.0%)
PTPN11	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
RB1	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
RET	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
SMAD4	1(1.3%)	0(0.0%)	0(0.0%)	1(1.9%)	0(0.0%)
SMARCB1	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
SMO	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
SRC	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
STK11	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)
TP53	17(22.4%)	7(41.2%)	1(16.7%)	9(17.3%)	0(0.0%)
VHL	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)	0(0.0%)