Table 2. Rate of overall survival ADCs by patients' characteristics.
Variables | Categories | ADCs (n = 435) | P-value | CERVICAL CA (n = 34) | P-value | KAPOSI SARCOMA (n = 184) | P-value | NON HODGKIN LYMPHOMA (n = 217) | P-value | ||||||||
1y | 5y | 10y | 1y | 5y | 10y | 1y | 5y | 10y | 1y | 5y | 10y | ||||||
Total | 77.0±2.0 | 67.7±2.4 | 61.1±2.9 | 90.9±5.0 | 87.3±6.0 | 78.5±9.9 | 86.9±2.5 | 79.1±3.2 | 72.8±4.0 | 66.6±3.2 | 55.0±3.5 | 48.2±4.3 | |||||
Gender | 0.613 | NE* | 0.498 | 0.874 | |||||||||||||
Male | 77.8±2.3 | 66.7±2.7 | 60.5±3.2 | - | - | - | 87.7±2.6 | 79.2±3.3 | 73.5±4.1 | 66.9±3.6 | 54.6±4.0 | 47.4±4.9 | |||||
Female | 76.8±4.5 | 71.7±4.9 | 63.8±6.1 | 90.9±5.0 | 87.3±6.0 | 78.5±9.9 | 76.9±11.7 | 76.9±11.7 | 65.9±14.3 | 65.1±7.6 | 57.0±8.0 | 51.3±9.0 | |||||
Age, years | 0.372 | 0.751 | 0.911 | 0.619 | |||||||||||||
18–34 | 82.4±4.3 | 76.2±5.0 | 65.1±6.7 | 100 | 100 | 66.7±2.7 | 89.6±4.9 | 83.7±6.1 | 69.6±9.0 | 67.1±8.5 | 57.8±9.7 | 57.8±9.7 | |||||
35–49 | 74.9±2.8 | 65.7±3.1 | 59.8±3.7 | 85.7±7.6 | 80.4±8.8 | 80.4±8.8 | 84.7±3.8 | 76.0±4.6 | 73.6±5.0 | 66.4±4.0 | 56.1±4.4 | 46.4±5.5 | |||||
50-max | 77.8±4.3 | 65.6±5.1 | 61.5±6.2 | 100 | - | - | 89.0±4.6 | 81.5±6.0 | 74.1±8.9 | 66.7±6.8 | 49.7±7.6 | 49.7±7.6 | |||||
IDVU | <0.001 | 0.060 | 0.002 | 0.276 | |||||||||||||
No | 80.7±2.3 | 73.2±2.7 | 67.7±3.5 | 91.3±5.9 | 91.3±5.9 | 73.0±17.0 | 90.0±2.5 | 83.4±3.3 | 77.8±4.4 | 68.0±4.2 | 58.1±4.7 | 54.6±5.5 | |||||
Yes | 69.3±3.9 | 56.4±4.3 | 48.6±4.8 | 90.0±9.5 | 80.0±12.6 | 80.0±12.6 | 74.8±7.3 | 62.5±8.3 | 53.8±9.1 | 64.7±5.0 | 51.4±5.4 | 42.0±6.2 | |||||
AIDS event | 0.024 | 0.273 | 0.162 | 0.022 | |||||||||||||
No | 79.0±2.6 | 73.4±2.9 | 65.4±4.0 | 90.5±6.4 | 90.5±6.4 | 90.5±6.4 | 88.8±3.3 | 86.3±3.7 | 74.8±6.3 | 70.5±4.0 | 61.8±4.3 | 55.5±5.8 | |||||
Yes | 74.3±3.3 | 60.4±3.8 | 55.2±4.1 | 91.7±8.0 | 81.5±11.9 | 61.1±19.8 | 85.0±3.8 | 72.2±5.0 | 70.2±5.2 | 60.2±5.5 | 44.4±5.8 | 37.8±6.1 | |||||
Coinfection | 0.075 | 0.957 | 0.129 | 0.895 | |||||||||||||
No | 78.6±2.6 | 70.8±3.0 | 67.4±3.5 | 85.7±9.3 | 85.7±9.3 | 85.7±9.3 | 88.8±2.8 | 82.1±3.6 | 76.5±4.6 | 65.5±4.7 | 55.5±5.0 | 55.5±5.0 | |||||
Yes | 75.0±3.2 | 63.61±3.7 | 53.7±4.5 | 94.7±5.1 | 88.8±7.5 | 76.1±13.4 | 82.8±5.2 | 72.5±6.3 | 64.7±7.7 | 67.7±4.5 | 54.8±5.0 | 44.2±6.0 | |||||
cART | 0.001 | 0.660 | 0.007 | 0.024 | |||||||||||||
No | 63.7±5.5 | 51.7±5.9 | 49.6±6.0 | 90.0±9.5 | 90.0±9.5 | 90.0±9.5 | 67.4±9.5 | 58.9±10.0 | 58.9±10.0 | 55.5±7.7 | 39.2±7.8 | 35.9±7.8 | |||||
Yes | 80.0±2.2 | 71.3±2.5 | 63.6±3.2 | 91.3±5.9 | 86.5±7.3 | 74.1±13.0 | 90.0±2.4 | 82.4±3.2 | 75.0±4.3 | 69.4±3.5 | 59.3±3.9 | 51.7±4.9 | |||||
CD4+ count, cell/mm3 | <0.001 | 0.003 | 0.001 | 0.001 | |||||||||||||
200-max | 84.3±2.6 | 76.6±3.2 | 70.6±4.2 | 96.1±3.8 | 96.1±3.8 | 96.1±3.8 | 94.1±2.9 | 89.6±4.1 | 86.2±5.2 | 74.6±4.3 | 62.9±5.0 | 53.2±6.9 | |||||
0–199 | 64.3±3.6 | 53.7±3.9 | 49.3±4.1 | 71.4±17.1 | 57.1±18.7 | 42.9±18.7 | 78.8±4.6 | 69.1±5.3 | 64.3±5.9 | 50.8±5.4 | 39.5±5.3 | 36.9±5.6 | |||||
Nadir CD4+ count, cell/mm3 | <0.001 | 0.085 | 0.001 | 0.033 | |||||||||||||
≥200 | 87.4±3.2 | 81.3±3.8 | 77.9±4.9 | 100 | 100 | 100 | 97.9±2.1 | 93.0±3.9 | 85.9±7.8 | 73.3±6.3 | 63.9±7.1 | 63.9±7.1 | |||||
50–199 | 69.3±3.5 | 77.7±3.1 | 61.4±4.4 | 75.0±15.3 | 62.5±17.1 | 62.5±17.1 | 88.8±3.7 | 84.0±4.5 | 75.6±6.1 | 69.8±4.6 | 59.2±5.1 | 49.9±6.6 | |||||
<50 | 67.5±4.1 | 54.5±4.5 | 48.8±4.9 | 90.0±9.5 | 90.0±9.5 | 90.0±9.5 | 75.5±5.7 | 61.9±6.6 | 58.8±7.0 | 56.8±6.2 | 42.8±6.3 | 37.1±6.8 | |||||
HIVRNA, copies/mL | 0.020 | 0.841 | 0.015 | 0.032 | |||||||||||||
Undetectable | 84.8±3.5 | 77.8±4.3 | 72.6±5.3 | 91.7±7.9 | 91.7±7.9 | 61.1±25.5 | 97.6±2.3 | 91.2±5.0 | 86.1±6.8 | 73.2±6.1 | 64.4±6.8 | 64.4±6.8 | |||||
Positive | 70.8±2.8 | 60.0±3.2 | 54.8±3.6 | 90.5±6.4 | 84.8±8.1 | 84.8±8.1 | 80.4±3.9 | 71.7±4.6 | 67.5±5.2 | 60.2±4.2 | 47.1±4.5 | 40.2±5.1 |
Note: Plus minus are value standard error, P value are from long rank test. - The sample size was too small for Kaplan Meier analysis.
*NE, not evaluable. ADCs: AIDS-defining cancers, IVDU: Intravenous Drug Use, cART: combined antiretroviral therapy; CA: cancer.