Figure 3. Behavioural profile of female 51KO and WT.

Overall, female 51KOs and WTs performed similar in all presented behavioural tests. Open field: (A) Total distance travelled and (B) time in inner zone. Elevated plus maze: (C) Total distance travelled and (D) percentage of the relative time in the open arm. Dark light box: (E) Time in the lit compartment and (F) number of entries to the lit compartment. Y-maze: (G) Percentage of novel arm entries of total arm entries and (H) the percentage of distance travelled in the novel arm. The striped lines in the graphs of the Y-maze represent the 33% change level of the novel arm measurements. Forced swim test: (I) Time spent struggling, swimming or floating and (J) latency till the first observed floating episode. * P<0.05.