Skip to main content
. 2014 Apr 23;9(4):e95723. doi: 10.1371/journal.pone.0095723

Figure 1. Schematic outline of fiber constructs with YSA peptide insertion investigated in this study.

Figure 1

(A) Short-shafted chimeric fibers with the HAdV-5 tail fused to the shaft and knob of the HAdV-41 short fiber. (B,C) Long-shafted chimeric fibers containing the HAdV-5 tail and wild-type (B) or mutant (C) shaft fused to the HAdV-41 short fiber knob. (D) CAR binding-ablated HAdV-5 fibers. YSA peptide insertion sites are indicated by loops. Insertion of the linker sequence in different positions of the HAdV-5 fiber knob IJ loop resulted in loss of trimerization capacity (data not shown) and viruses were not produced for this insertion site.