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. 2014 Apr 23;9(4):e95723. doi: 10.1371/journal.pone.0095723

Figure 3. Efficiency and selectivity of transduction by Ad vectors containing short-shafted chimeric fibers with genetic insertion of the YSA peptide.

Figure 3

(A) Transduction of EphA2-positive and EphA2-negative cells by pseudotyped Ad vectors containing short-shafted chimeric fibers with genetic insertion of the YSA peptide in comparison to matching vectors with genetic insertion of the RGD4C peptide. Cells were transduced in quadruplicates. (B) Transduction of EphA2-positive PANC-1 cells after competition with soluble YSA peptide or with control peptide of randomized sequence. Cells were transduced with pseudotyped Ads in triplicates. Columns and error bars show mean values and standard deviations of β-Gal activity, respectively. RLU, relative luminescence units; */#p<0.05, **/##p<0.01 ***p<0.001 versus 5T/41sSK (*) or 5T/41sSK-HI-RGD (#).