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. 2014 Apr 23;9(4):e95723. doi: 10.1371/journal.pone.0095723

Figure 8. Transduction of living tissue slices of human melanoma metastases ex vivo.

Figure 8

(A–E) Living tissue slices of melanoma metastases from 5 different patients were transduced with 1010 vp/slice of genomically fiber-modified, EphA2-targeted Luc/GFP reporter and control viruses. The number of transduced slices per virus was dependent on the size of the biopsy and was n = 4 (A,B), n = 3 (C), n = 2 (D) and n = 5 (E). Luciferase reporter gene expression was quantified 3 days post-transduction. Columns (A–E) and error bars (A,B,C,E) show mean values and standard deviations, respectively. RLU, relative luminescence units. */#p<0.05 versus 5T/41sSK (*) or 5KO1 (#).